PLASMA LEVELS OF MDA AND LIPID PROFILE IN PATIENTS WITH HYPERTHYROIDISM

Abstract

Hyperthyroidism is an endocrine condition of the thyroid gland characterized by low TSH levels and high thyroxine (T4) and triiodothyronine (T3) hormone levels. Our goal was to determine the oxidative status in hyperthyroidism patients by measuring malondialdehyde (MDA) and find out its correlation with the thyroid function hormones and lipid profile in the plasma. Sixty patients with overt hyperthyroidism were included in the study with 30 heathy people with normal thyroid function. The thyroid hormone profile has shown that hyperthyroidism patients have significant (P<0.05) low levels of TSH (0.53±0.11 mIU/mL), but significant (P><0.05) high levels of T3 (6.40±0.91 nmol/L) and T4 (175.36±21.27 nmol/L) in their plasma, compared to normal thyroid people. Hyperthyroidism patients have shown non-significant (P>0.05) alterations in the plasma triglycerides (104.08±17.13 mg/dL), and cholesterol (149.89±12.07 mg/dL), compared to the plasma of normal control. But, they have shown significant (P <0.05) lower levels of HDL (42.39±6.81 mg/dL) compared to the control. Furthermore, hyperthyroidism patients have shown significant (P><0.05) higher levels of MDA (1.63±0.60 µmol/L) in their plasma compared to the plasma of normal thyroid function people (0.54±0.13 µmol/L). The high levels of MDA in hyperthyroidism patients suggested lipid peroxidation, which occurs from an imbalance between oxidants and antioxidants not just in the thyroid gland but also systemically, as assessed in the plasma.>