EFFECTS OF METHANOLIC LEAVES EXTRACT OF DATURA ALBA NESS ON HAEMATOLOGICAL PARAMETERS IN MALE WISTAR RATS

Abstract

Haematological parameters are essential parameters that need to be assessed periodically to ascertain the levels and ensure that it is within the normal values in other to maintain good health. Blood cells are important because they are responsible for out their specific role as: RBC is for oxygen, and nutrient transportation, WBC is for body defense and platelet is for coagulation. Decrease in any of these formed elements may affects the body system and it must be within limits. The aim of the study is to evaluate the Effects of Datura alba ness Leaves extract on haematological parameters in male Wistar rats. 20 rats were randomly selected and placed into four groups with five rats per group. The control group was fed with rodent chow and water, the low dose group was given 500mg/kg/bwt of the extract, medium dose group was given 1000mg/kg/bwt of the extract, the high dose group was given 2000mg/kg/bwt of the extract. All the extracts were given orally. Administration lasted for 21 days and on the 22nd day, animals were weighed and sacrifice, blood samples were collected for haematological analysis. Data were analysed using ANOVA and SPSS version 25 were used and p < 0.05 was said to be significant. The results shows significant decrease in the white blood cells of the animals administered with both low and medium dose of the extract. Result also shows significant decrease in the red blood cells of the rats administered with medium dose of the extract. No significant difference in platelet counts. There is no significant difference is the haematological indices and differentials (neutrophils, monocytes, leucocytes and eosinophil of the rats administered with the extract. The result showed that, this extract induced dyslipidemia in male Wistar rats.