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TLR4 ASP299GLY (RS4986790) AND THE PREDISPOSITION TO GRAM-NEGATIVE GALLBLADDER EMPYEMA IN ACUTE CALCULOUS CHOLECYSTITIS: A PROSPECTIVE-RETROSPECTIVE COHORT STUDY

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dc.contributor.authorBunyodjon N. Kurbonboev
dc.contributor.authorKamolliddin Z. Salakhiddinov
dc.contributor.authorEduard A. Vasilevskiy
dc.contributor.authorOmonjon T. Dadabaev
dc.date.accessioned2026-03-06T20:32:04Z
dc.date.issued2026-03-06
dc.description.abstractGallbladder empyema, the bacterially infected and pus-filled form of acute cholecystitis, carries a conversion rate to open surgery that is three to four times higher than for gangrenous cholecystitis alone and is the single strongest predictor of systemic sepsis in this disease. The innate immune receptor TLR4 governs the first-line cellular response to gram-negative lipopolysaccharide, and its Asp299Gly missense variant (rs4986790) reduces signal transduction efficiency. Whether this functional hyporesponsiveness translates into a clinically recognisable predisposition to empyema in a real-world surgical cohort has not been studied.
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dc.identifier.urihttps://ejird.journalspark.org/index.php/ejird/article/view/1974
dc.identifier.urihttps://asianeducationindex.com/handle/123456789/118230
dc.language.isoeng
dc.publisherJournal Park Publishing
dc.relationhttps://ejird.journalspark.org/index.php/ejird/article/view/1974/1912
dc.rightshttps://creativecommons.org/licenses/by-nd/4.0
dc.sourceEuropean Journal of Interdisciplinary Research and Development ; Vol. 49 (2026); 47-55
dc.source2720-5746
dc.subjectToll-like receptor 4; TLR4 Asp299Gly; gallbladder empyema; acute cholecystitis; innate immunity; gram-negative infection; single-nucleotide polymorphism.
dc.titleTLR4 ASP299GLY (RS4986790) AND THE PREDISPOSITION TO GRAM-NEGATIVE GALLBLADDER EMPYEMA IN ACUTE CALCULOUS CHOLECYSTITIS: A PROSPECTIVE-RETROSPECTIVE COHORT STUDY
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Article

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