ALTERATION IN THE CONVULSIVE EFFECT OF KYNURENINE, CORAZOL AND CAFFEINE UNDER THE ACTION OF BICUCULLINE

Abstract

In male mice of two strains SHR and C57BL/6, pretreatment with bicuculline (1 mg/kg, s.c.), an antagonist of GABA-A receptors, potentially the convulsant effect of pentylenetetrazole (40mg/kg, ip.) and caffeine (200mg/kg, ip.) and had no effect on that of Lkynurenine (11 meg, i.c.v.). Data suggest that the convulsant effect of L-kynurenine, an endogenous convulsant from neuroactive tryptophan metabolites, is not related to GABA-A receptors. Other data reported elsewhere (e.g. the antagonism of phenibut and baclofen, agonists of GABA-B receptors, to L- kynurenine) suggest that kynurenine-induced seizures are related to GABA-B receptors