Plasma Nesfatin-1 Level in Relation to Dyslipidemia and VEGF-A with Poor Control Type 2 Diabetes Mellitus

Abstract

NUCB2/nesfatin-1 plays a role in physiological regulation, it provides you with energy and stimulates the development of brown adipocytes through a pathway and increased expression. In the pathophysiology of diabetes mellitus, the vascular endothelial growth factors A(VEGF-A) is of critical importance. The aim of this study to assessment level of nesfatin-1, lipid profile and VEGF-A in a group of patients with poor control type 2 diabetes mellitus (T2DM) and compare it with apparently healthy control and study the correlation with each other’s. There were 180 participants in the research study,70 control persons and 110 T2DM patients. Serum cholesterol, triglyceride, HDL and LDL were calculated by COBAS INTEGRA 400 plus. Nesfatin-1 and VEGF-A levels were estimated using enzyme-linked immunosorbent assay(ELISA) kit. The levels of Nesfatin-1 and VEGF-A in the patients group and in the normal control found to differ significantly (p < 0.001). Significant positive correlation was seen between the level of Nesfatin-1 and VEGF-A (P <0.001) .Non-significant correlation was found between Nesfatin-1 and VEGF-A with each of serum cholesterol, triglyceride,high density lipoprotein(HDL), and low density lipoproteins(LDL) in patients with poor control diabetes (p> 0.05) . In conclusion, the correlation between VEGF-A and nesfatin-1 indicating that Nesfatin-1 levels rise in tandem with VEGF-A levels. The absence of correlation between Nesfatin-1 and VEGF-A with lipid abnormalities demonstrate that lipid problems related to diabetes could not affect how angiogenesis is regulated.