DISRUPTION OF CATECHOLAMINE METABOLISM IN WOMEN WITH MICROVASCULAR ANGINA

Abstract

This scientific article examines the relationship between the activity of the sympatho-adrenal system and monoamine oxidase (MAO) in women diagnosed with microvascular angina. A total of 28 women were examined and divided into three groups. Group I, the control group, consisted of 10 healthy women; Group II included 8 women diagnosed with stable exertional angina of functional class II; and Group III included 10 women with microvascular angina. According to the obtained results, patients with microvascular angina demonstrated increased activity of the sympatho-adrenal system. It was also established that the MAO enzyme, which is responsible for the deamination of catecholamines, showed a significant decrease in its activity. This condition is believed to result from increased lipid peroxidation processes, which lead to enhanced and prolonged toxic effects of catecholamines on the myocardium.