Protective Effect of Selenium Against Oxidative Stress Induced Potassium Dichromate Toxicity in Male Rats

Abstract

The purpose of this study was to investigate the potentially protective effect of selenium against potassium dichromate toxicity and to evaluate the toxicity of potassium dichromate in male rats. One indicator of oxidative stress is the presence of statistically significant levels of malondialdehyde in liver and kidney tissue as a result of the ability of potassium dichromate to produce stress-inducing electrolytes Increased oxidized fat, decreased high-density lipids, and increased low-density lipids have been observed in male rats Injury to the liver cell , kidneys, decreased activity of catalase and glutathione enzymes were observed in the liver and kidneys, and increased (TBARS) levels were observed in the liver and kidneys, noting histological changes in the kidneys and liver that confirm enzymatic changes. On the other hand, histological sections of the kidneys of the treated group showed potassium dichromate-induced contraction of the renal glomeruli and dilation of Bowman's sac, congestion, and hemorrhage of the vessels near the Malpighian body, and increased thickness of its walls. The presence of protein casts in the lumen of the renal tubules, haemorrhage between the tubules, dilation, and leukocyte infiltration and l. This study was performed in adult male white rats (24 rats), divided into 4 equal groups (6 rats) each. At the end of the experiment, blood was drawn from the rat ear vein in all groups for evaluation. Biochemical parameters in blood erase, and samples from liver, kidney were collected from rats for histological examination.