Design, Synthesis of new imidazole derivatives as potential antibacterial agents

Abstract

In this study, heterocyclic compounds stabilized on benzoamidazole were prepared by reacting 5-((1H-imidazol-1-yl)methyl)-1,3,4-thiadiazol-2-amine with various aromatic aldehydes, including 1H-indole-3-carbaldehyde and [1,1'-biphenyl], new Schiff's base derivatives a1-a5 have been created.4-(methylthio)benzaldehyde, 4-(phenoxymethyl) benzaldehyde, 1-naphthaldehyde, and 4-carbaldehyde. in ethanol at 80 °C with glacial acetic acid acting as a catalyst in a good yield. All compound's antimicrobial qualities were examined. The bulk of the compounds are shown to be the most effective against applicable bacterial strains, according to a review of the biological activity data. The compounds (a1 and a3) exhibited the best inhibition against strains of S. aureus and E. coli. This makes it important to note that Schiff's base derivatives including imidazole and nuclei have emerged as a key field of antibacterial research. These derivatives could be a solution to many problems if they are worked on and developed by researchers.