ETORICOXIB VERSUS PIROXICAM IN ACCENTUATING THE COGNITIVE FUNCTIONS

Abstract

Cognitive functions are processes of knowing. When it is impaired, reviving is needed. Studies to bustle off the psychomotor activities using COX-1 inhibitors revealed variable results. Aim: To evaluate the effects of a single oral dose of etoricoxib and piroxicam (COX-2 inhibitors) on cognitive activity in healthy, young volunteers. Subjects and Methods: Thirty-two healthy young volunteers were participated, allocated into two groups. After a7-day washed-out period, each participant was randomly given a single oral dose of either etoricoxib (90mg) or piroxicam (10mg) or placebo. Psychomotor tests were performed to record their sensory and motor reactions. Results: the placebo-administered subjects had non-significant changes in both choice reaction time and critical flicker fusion. Etoricoxib-administered subjects had a significantly reduced recognition reaction time without a significant effect on motor reaction time. While piroxicam-administered ones had a significant reduction in motor reaction time without a significant effect on recognition reaction time. All drug-given individuals had a non-significant change in choice reaction time when compared with corresponding baseline and placebo values.