BASIS OF PATHOGENESIS OF CHF WITH PRESERVED EJECTION FRACTION

Abstract

Despite numerous studies of CHF with preserved EF, the mechanism of its formation and progression is not fully unexplored. In addition to age and concomitant diseases, microvascular dysfunction plays an important role. An actual task is to study the combination of risk factors, as well as to determine the leading link in the pathogenesis of CHF with preserved EF. In the pathogenesis of CHF in men and women, there are key differences that can affect not only the clinical course of the disease, but also its short-term and long-term prognosis, since women more often experience concentric LV remodeling and, as a consequence, the formation of heart failure with preserved EF, whereas for men, the formation of heart failure with low EF is more typical[1]. Nowadays, the problem of heart failure (HF) has become a global public health problem, given the fact that its prevalence is constantly increasing. The number of patients with heart failure worldwide is about 26 million, of which 50% are patients with heart failure with preserved ejection fraction(HFpEF)[2].