Liver Cirrhosis in Albino Male Rats Induced by Sunset Yellow (E110) Dyes

Abstract

The toxic effect of sunset yellow (E110) were studied in albino male rats. Twenty albino male rats mean weight (75± 2 gm) were used and divided into two equal groups: 1st group (Control) group contain (10) rats feed on healthy pellet, 2nd group (treated group) contain 10 rats’ daily intake for 120 days by gavage (2g /1 kg b.w) Sunset yellow (E110) dissolved in distal water. Biochemical analysis of serum at day 60 & 120 of experimental by analysis catalase (Iu/mg), Malonaldehyde (MDA) (mol/L), serum Alanine transaminase (ALT) and Aspartate transaminase (AST)(Iu/l). Liver tissue were taken for histopathology changes at days (120) and stained by H&E and masson trichrome. Result showed significant decrease P <0.05 in catalase & significant increase in MDA, ALT &AST in treated group at 60 & 120 days. Liver cirrhosis & granuloma with necrosis is the most impudent lesion in treated group.>