THE PROBLEM OF INFECTION IN MEDICINE

Abstract

Analyzed were the problems of infection in medicine covering the outstanding achievements in the field of microbiology, development of effective antibacterial drugs - first sulfonamides, and then antibiotics with the emergence of epidemiology and the creation of vaccines. Established were the features of evolution of the infectious process due to the «return» of infections that were inherited in the past centuries, and associated with the emergence of new infectious diseases, 35 of which are the result of interspecies «jumps» of the pathogens from animals to humans; ascertained were the changes in the behavior of the bacteria with their recent characteristic «social» behavior, manifested primarily in the ability to form structured communities of bacteria. Stressed was the need for adequate laboratory diagnosis of infections involving the use of current advances in genetics, molecular biology, metagenomic and proteomic technologies, opening up the perspectives for a fundamental change in the quality of etiologic diagnosis, the use of amplification test-systems, blood cultures, mass spectrometry, etiotropic and efferent therapy. Furthermore, attention should be paid to the development of new methods of usage of antibacterial agents and monitoring their effectiveness, and implementation of the principles of preventive rotation of broad-spectrum antibiotics.