Respiratory Dysfunction of Patients with Severe Burn Injury

Abstract

In the structure of multiple organ disorders, complications and causes of mortality in burn disease, respiratory pathology occupies one of the leading places (1,2,12), while combined inhalation injury (IT), which is observed in 30-40% of burn patients, significantly aggravates course, is accompanied by a more frequent development of pulmonary complications, higher mortality and is the main cause of respiratory failure (,3,6,8,11,13,16). The most important factors that damage the mucous membrane of the respiratory tract during IT are a variety of combustion products in an enclosed space. The developing mucosal edema is primarily due to such mediators as histamine, bradykinin, prostacyclin, and bronchospasm and increased pulmonary vascular resistance are due to the release of thromboxane and complement components (8.15).