THE ROLE OF PENTRAXIN 3, KLOTHO-PROTEINS, ANTI- TPO AND MAGNESIUM IN SERUM OF SUBCLINICAL HYPOTHYROIDISM WOMEN PATIENTS

Abstract

Thyroid hormones, plays an important and essential functions in metabolic processes. Subclinical hypothyroidism happens when someone have exposure to elevated thyroid-stimulating hormone levels with normal values of thyroxine. Pentraxin 3 is an important endogenous mediator for defenses innate immunity, and its analogous molecule of inflammation C-reactive protein molecule. Klotho protein plays an essential multiple physiological and pathological functions in several organs and tissues of the body. Magnesium is a cofactor for many enzymes Materials and methods: The sixty five women patients suffering have Subclinical hypothyroidism women were participated, their ages ranged from 25 to 40 years. Biochemical measurements of thyroid hormones levels by Minividas technique, while Anti TPO protein measured by kit from mybiosource company, PTX3, Klotho protein from Sun Long Biotech – China, and Mg2+ measured with of Biomaghreb kit. Results: There was no significant different (P>0.05) in T3, T4 and Klotho protein levels women patients group when compared to women control group. There was : a highly significant increase (<0.01) in TSH level, a significant increase (p<0.05) in the serum levels of PTX3 , highly significant increase (p<0.001) in Anti-TPO and a highly significant deceased (≤ 0.01) in the serum levels of Mg2+ mg/dl in Subclinical hypothyroidism group when compared with control group. Conclusion:PTX3 may be relatively independent marker for prognosis of subclinical hypothyroidism.