MORPHOMETRIC INDICATORS OF THE HISTOLOGICAL STRUCTURES OF THE SPLEEN OF WHITE RATS IN IRON MICROELEMENTOSIS EVALUATION

Abstract

The article presents data on changes in the structural and functional state of the spleen of white rats with alimentary iron deficiency depending on age periods. The results showed that in alimentary iron deficiency, an increase in the relative area of connective tissue elements in this organ, a decrease in the morphometric parameters of lymphoid tissue, the number of lymphoid cells, and the level of expression of immunohistochemical markers were revealed. These changes mean a decrease in the immune response and a weakening of the body's defense capabilities. Morphofunctional changes in the spleen in alimentary iron deficiency manifest differently depending on the age periods of white rats, which contributes to a deeper understanding of the influence of alimentary factors on immune homeostasis.