Threshold Concept of Collagen Deposition as a Marker of Myocardial Interstitial Fibrosis in Atrial Fibrillation Cases

Abstract

Procollagen type I carboxyterminal propeptide (P1CP) and carboxy-terminal telopeptide of collagen type I (C1TP) were presented as peptides that reflect collagen synthesis and degradation and offer a much more helpful tool for detecting ECM alterations at a distance. In past years, clinical trials have been conducted to evaluate the use of these peptides as either prognostic or diagnostic biomarkers in patients with heart failure (HF). This study would investigate whether the combination of a collagen turnover marker and a collagen deposition marker is associated with different subtypes of atrial fibrillation (AF). As there is a new trend to investigate the roles of these markers in other cardiac diseases, this study would investigate whether the combination of the collagen turnover marker and the collagen deposition marker is associated with different subtypes of atrial fibrillation