Clinical Review of Thalassemia: Kinds, Signs Management, and Globin Structure

Abstract

Thalassemia is a blood disease in which the typical hemoglobin is synthesized in minor quantities than normal. It is genetic disease consequently it passed from parents via their genes. Thalassemia patients cannot synthesize sufficient typical hemoglobin, that causes serious anemia. Hemoglobin is present in erythrocytes and transports O2 to all organs of the body. Around the world, there are approximately 30 million carriers in addition to about 10000 babies have thalassemia annually. In fact, two main types of thalassemia are found. These types are Alpha thalassemia which affected by Alpha globin gene and Beta Thalassemia which affected by Beta globin gene. In this review we focus on thalassemia disorder, kinds and its management.