UNIQUE PRINCIPLES OF COMPLEMENT BINDING REACTION

Abstract

The unique ability of complement to bind specifically to antigen-antibody complexes of different nature has been utilised in the complement binding reaction (CBR) proposed in 1901 by J. Borde and O. Jangou. The particular advantage of the complement binding reaction is that the nature of the antigen involved (corpuscular or soluble) is irrelevant, since complement binds to the Fc-fragment of any IgG and IgM antibody, irrespective of its antigenic specificity.