Dose PPP1R1A Polymorphism are Effected to Increased Risk of Heart Disease?

Abstract

Apolipoprtein is the essential material for transport cholesterol and triglyceride in revers process and may play important role in lipid overload in body and involving the risk of cardiovascular disease (CVD). Although there are sufficient traditional risk factors for diabetes and heart disease, our understanding of the genetic risk factors is still lacking. A case-control research was carried out to determine how much of a role genetic factors have in relation to other risk factors. A 94 morbidly obese and 70 normal non-obese that matched in gender and age was collected. Measurements were made of biochemical variables, and polymorphism was genotyped using the polymerase chain reaction (PCR- RFLP). To evaluate the strength of the link between genetic and non-genetic factors, For the clinical parameter and odds ratio (OR), the mean, standard error (SE), and T test were calculated with a 95% confidence interval. The findings indicate that compared to non-obese individuals, morbidly obese individuals had increased levels of triglycerides, very low density lipoprotein, low density lipoprotein, blood pressure, and cholesterol. However, the value of high density lipoprotein between the two groups does not demonstrate any significant variations. The research found a substantial correlation between the genotype of PPP1R1A and morbidly obesity who are more at risk of DM type2 and heart disease (OR: 1.26, 95%CI: 0.91-1.60, P= 0.0003). However, more case-control research is necessary to draw a firmer conclusion.