Mitochondrial Dysfunction in Neurodegenerative Diseases
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Scholars Digest Publishing
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This review discusses the following mechanisms damage and dysregulatory effects on mitochondria: activation of nonspecific response mechanisms to disruption of the native structure of proteins – unfolded protein response (UPR); loss of mitochondrial function proteins; direct toxic effects of defective proteins on mitochondria; mitochondrial activation PGK mechanisms; dysregulation of the processes of utilization, division and fusion of mitochondria; traffic disruption and intracellular distribution of mitochondria.